A simple, specific, accurate, precise and reproducible method has been developed and validated for the simultaneous estimation of olmesartanmedoxomil andmetoprolol succinate in their combined tablet dosage form using simultaneous equation method.The wavelength for simultaneously detection were 256nm and 223 nm selected for olmesartanmedoxomil and metoprolol succinate, respectivelyin methanol.The method was found to be linear in concentration range of 5-25 μg/ml and 10-50 μg/ml for olmesartanmedoxomil and metoprolol succinate,respectively.The % recoveries were found to be 98.38% – 101.1 % and 98.3– 101.75 % for olmesartanmedoxomil and metoprolol succinate,respectively.LOD were found to be 1.275 μg/ml and 1.297 μg/ml for olmesartanmedoxomil at 256nm and 223 nm and 2.264 μg/ml and 2.692 μg/ml for metoprolol succinate at 256nm and 223 nm,respectively. Methods were statistically validated for accuracy, precision, specificity, LOD, LOQ, robustnessand ruggedness according to ICH guidelines and can be used for analysis of combined dosage form.
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